2,3-二氢-1,2-噻唑 1,1-二氧化物

反应条件: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a solution of 2,3-dihydroisothiazole-1,1-dioxide (0.100 g, 0.8 mmol) in methanol (1 mL) was added 25% sodium methoxide in methanol (0.181 g, 0.8 mmol) and the solution stirred at 60° C. for 2 hrs and at 70° C. for 3 hrs. The mixture was concentrated and suspended in 1 N aqueous hydrochloric acid. The aqueous mixture was extracted with ethyl acetate (3×), and the organic layers dried (anhydrous sodium sulfate), filtered, and concentrated in vacuo. The crude material was purified by silica gel chromatography (0-6% methanol/methylene chloride) to give the product (0.011 g, 13%). 1H NMR (300 MHz, CDCl3) δ 4.53 (br s, 1H), 4.33-4.29 (m, 1H), 3.48-3.30 (m, 3H), 3.37 (s, 3H), 3.19-3.13 (m, 1H). 13C NMR (100 MHz, CDCl3) δ 80.8, 57.1, 53.3, 48.7. The mixture was concentrated The aqueous mixture was extracted with ethyl acetate (3×) the organic layers dried (anhydrous sodium sulfate) filtered concentrated in vacuo The crude material was purified by silica gel chromatography (0-6% methanol/methylene chloride)