2-(4-氯苯基)-2-甲基丙甲腈

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Commercially available 2-(4-chlorophenoxy)-2-methylpropanenitrile (Maybridge), HCl gas and ethanol were processed using the method described for Example 4A to obtain the titled compound. MS (ESI+) m/z 242 (M+H)+.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 19.57 g. (0.1 moles) of 2-(p-chloro-phenoxy)- 2-methyl-propionitrile are reacted under stirring for 34 hours with 17.83 g. (0.2 moles) of 2-amino-2-methyl-1-propanol in the presence of 0.66 g. (0.003 moles) of zinc acetate catalyst at a temperature of 140°-150°C. The reaction takes place under an intensive development of ammonia gas. When the development is finished, the mixture is cooled, dissolved in 300 ml. of chloroform and the solution washed with water to neutral reaction. After drying the solution over anhydrous magnesium sulphate it is evaporated to dryness. The green-yellow colored oil (26.5 g.), is subjected to fractional distillation in vacuo. The main fraction is a product of 23.6 g. (yield 88%), mp.: 98°-100°C/0.02 mmHg. The distilled product crystallizes after standing for 48 hours, Mp. 59°-61°C. at a temperature of 140°-150°C the mixture is cooled dissolved in 300 ml of chloroform and the solution washed with water to neutral reaction After drying the solution over anhydrous magnesium sulphate it is evaporated to dryness The green-yellow colored oil (26.5 g.), is subjected to fractional distillation in vacuo The distilled product crystallizes after standing for 48 hours

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 19.57 g (0.1 moles) of 2-(p-chlorophenoxy)-2-methyl-propionitrile are reacted under stirring for 34 hours with 17.83 g (0.2 moles) of 2-amino-2-methyl-1-propanol in the presence of 0.66 g (0.003 moles) of zinc-acetate catalyst at a temperature of 140°-150° C. The reaction takes place under an intensive development of ammonia gas. When the gas development is finished, the mixture is cooled, dissolved in 300 ml of chloroform and the solution washed with water to neutral reaction. After drying the solution over anhydrous magnesium sulphate, it is evaporated to dryness. The green-yellow colored oil (26.5 g) is subjected to fractional distillation in vacuo. The main fraction is a product 2-[(p-chlorophenoxy)-isopropyl]-4,4-dimethyl-2-oxazoline of 23.6 g (yield 88%), m.p.: 98°-100° C./0.02 mmHg. The distilled product crystallizes after standing for 48 hours, m.p.: 59°-61° C. the mixture is cooled the solution washed with water to neutral reaction After drying the solution over anhydrous magnesium sulphate, it is evaporated to dryness The green-yellow colored oil (26.5 g) is subjected to fractional distillation in vacuo The distilled product crystallizes