2,2,2-trifluoroethyl carbonochloridate

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The product of Example 42 and 2,2,2-trifluoroethyl carbonochloridate were treated using a method similar to that described in Example 128 to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ 11.61 (s, 1H), 8.36-8.27 (m, 2H), 8.07 (d, J=7.5, 1H), 8.03-7.96 (m, 1H), 7.95-7.87 (m, 1H), 7.45-7.36 (m, 4H), 4.67 (q, J=9.1, 2H), 4.56 (d, J=5.9, 2H), 3.68 (s, 2H); MS (ESI−) M/Z 467 (M−H)−.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The product of Example 42 and 2,2,2-trifluoroethyl carbonochloridate were treated using a method similar to that described in Example 128 to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ 11.61 (s, 1H), 8.36-8.27 (m, 2H), 8.07 (d, J=7.5, 1H), 8.03-7.96 (m, 1H), 7.95-7.87 (m, 1H), 7.45-7.36 (m, 4H), 4.67 (q, J=9.1, 2H), 4.56 (d, J=5.9, 2H), 3.68 (s, 2H); MS (ESI−) M/Z 467 (M−H)−.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The product of Example 42 and 2,2,2-trifluoroethyl carbonochloridate were treated using a method similar to that described in Example 128 to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ 11.61 (s, 1H), 8.36-8.27 (m, 2H), 8.07 (d, J=7.5, 1H), 8.03-7.96 (m, 1H), 7.95-7.87 (m, 1H), 7.45-7.36 (m, 4H), 4.67 (q, J=9.1, 2H), 4.56 (d, J=5.9, 2H), 3.68 (s, 2H); MS (ESI−) M/Z 467 (M−H)−.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 4-{5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-[1,4]diazepane-1-carboxylic acid 2,2,2-trifluoro-ethyl ester was prepared from 5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-[1,4]diazepan-1-yl-thiazol-4-one and 2,2,2-Trifluoroethyl chloroformate according to Example 133.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 4-{5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-[1,4]diazepane-1-carboxylic acid 2,2,2-trifluoro-ethyl ester was prepared from 5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-[1,4]diazepan-1-yl-thiazol-4-one and 2,2,2-Trifluoroethyl chloroformate according to Example 133.