2',5'-二氯苯丙酮

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a solution of 2',5'-difluoropropiophenone (2.12 g) in diethyl ether (20 ml) under ice-cooling was added bromine dropwise, and the mixture was stirred at room temperature overnight. To this reaction mixture was added ice and the diethyl ether layer was separated, followed by washing with water and saturated aqueous solution of sodium hydrogen carbonate in that order and dried over anhydrous magnesium sulfate (MgSO4). The either layer was concentrated under reduced pressure to provide the title compound. To this reaction mixture was added ice the diethyl ether layer was separated by washing with water and saturated aqueous solution of sodium hydrogen carbonate in that order dried over anhydrous magnesium sulfate (MgSO4) The either layer was concentrated under reduced pressure

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a solution of 2',5'-difluoropropiophenone (2.12 g) in diethyl ether (20 ml) under ice-cooling was added bromine dropwise, and the mixture was stirred at room temperature overnight. To this reaction mixture was added ice and the diethyl ether layer was separated, followed by washing with water and saturated aqueous solution of sodium hydrogen carbonate in that order and dried over anhydrous magnesium sulfate (MgSO4). The either layer was concentrated under reduced pressure to provide the title compound. To this reaction mixture was added ice the diethyl ether layer was separated by washing with water and saturated aqueous solution of sodium hydrogen carbonate in that order dried over anhydrous magnesium sulfate (MgSO4) The either layer was concentrated under reduced pressure

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a solution of 2′,5′-difluoropropiophenone (2.12 g) in diethyl ether (20 ml) under ice-cooling was added bromine dropwise, and the mixture was stirred at room temperature overnight. To this reaction mixture was added ice and the diethyl ether layer was separated, followed by washing with water and saturated aqueous solution of sodium hydrogen carbonate in that order and dried over anhydrous magnesium sulfate (MgSO4). The ether layer was concentrated under reduced pressure to provide the title compound. To this reaction mixture was added ice the diethyl ether layer was separated by washing with water and saturated aqueous solution of sodium hydrogen carbonate in that order dried over anhydrous magnesium sulfate (MgSO4) The ether layer was concentrated under reduced pressure

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a solution of 2′,5′-difluoropropiophenone (2.12 g) in diethyl ether (20 ml) under ice-cooling was added bromine dropwise, and the mixture was stirred at room temperature overnight. To this reaction mixture was added ice and the diethyl ether layer was separated, followed by washing with water and saturated aqueous solution of sodium hydrogen carbonate in that order and dried over anhydrous magnesium sulfate (MgSO4). The ether layer was concentrated under reduced pressure to provide the title compound. To this reaction mixture was added ice the diethyl ether layer was separated by washing with water and saturated aqueous solution of sodium hydrogen carbonate in that order dried over anhydrous magnesium sulfate (MgSO4) The ether layer was concentrated under reduced pressure

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a solution of 2',5'-difluoropropiophenone (2.12 g) in diethyl ether (20 ml) under ice-cooling was added bromine dropwise, and the mixture was stirred at room temperature overnight. To this reaction mixture was added ice and the diethyl ether layer was separated, followed by washing with water and saturated aqueous solution of sodium hydrogen carbonate in that order and dried over anhydrous magnesium sulfate (MgSO4). The either layer was concentrated under reduced pressure to provide the title compound. To this reaction mixture was added ice the diethyl ether layer was separated by washing with water and saturated aqueous solution of sodium hydrogen carbonate in that order dried over anhydrous magnesium sulfate (MgSO4) The either layer was concentrated under reduced pressure

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a solution of 2′,5′-difluoropropiophenone (2.12 g) in diethyl ether (20 ml) under ice-cooling was added bromine dropwise, and the mixture was stirred at room temperature overnight. To this reaction mixture was added ice and the diethyl ether layer was separated, followed by washing with water and saturated aqueous solution of sodium hydrogen carbonate in that order and dried over anhydrous magnesium sulfate (MgSO4). The ether layer was concentrated under reduced pressure to provide the title compound. To this reaction mixture was added ice the diethyl ether layer was separated by washing with water and saturated aqueous solution of sodium hydrogen carbonate in that order dried over anhydrous magnesium sulfate (MgSO4) The ether layer was concentrated under reduced pressure