1-氟-4-甲苯

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 4-Fluorotoluene (14 g) is added slowly with stirring to a solution of fuming nitric acid (18 g) and concentrated sulfuric acid (30 g) over 30 minutes and alternately warmed and cooled to keep the temperature between 40 and 50° C. This is followed by heating at 100° C. for 30 minutes more. The organic material is cooled and extracted with methylene chloride to give 16 g of 4-fluoro-2-nitrotoluene. alternately warmed cooled the temperature between 40 and 50° C The organic material is cooled extracted with methylene chloride

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The test described in Example 1 was repeated using 300 g of p-fluorotoluene, 660 g of acetic acid, 132 g of water, 6 g of cobalt acetate tetrahydrate, 5 g of sodium bromide and 5 g of sodium acetate. In a reaction time of 240 minutes, after conventional work-up, 330.5 g of p-fluorobenzoic acid (86.6% of the theory) was obtained, with a purity of 99.9%.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: p-Methylsulfinylbenzoyl chloride (0.2 mole) and p-fluorotoluene (0.2 mole) are refluxed together in trifluoromethanesulfonic acid for 6 hours according to the procedure of Chodroff and Klein, J.A.C.S. 70, 7209 (1948).

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: p-Methylsulfinylbenzoyl chloride (0.2 mole) and p-fluorotoluene (0.2 mole) are refluxed together in trifluoromethanesulfonic acid for 6 hours according to the procedure of Chodroff and Klein, J.A.C.S. 70, 7209 (1948).

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A 300-ml flask was charged with 16.6 g of 4-fluorotoluene, 30.0 g of NBS, 0.5 g of benzoyl peroxide and 150 ml of carbon tetrachloride, and the mixture was refluxed for 2.0 hours. The reaction mixture was cooled to room temperature, and the formed precipitate was removed by filtration and the residual CCl4 solution was washed with dilute alkali and then with water, dried over Na2SO4, and evaporated under reduced pressure to give 28.8 g of crude 4-fluorobenzyl bromide. the mixture was refluxed for 2.0 hours the formed precipitate was removed by filtration the residual CCl4 solution was washed with dilute alkali with water, dried over Na2SO4 evaporated under reduced pressure

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A 300-ml flask was charged with 16.6 g of 4-fluorotoluene, 30.0 g of NBS, 0.5 g of benzoyl peroxide and 150 ml of carbon tetrachloride, and the mixture was refluxed for 2.0 hours. The reaction mixture was cooled to room temperature, and the formed precipitate was removed by filtration and the residual CCl4 solution was washed with dilute alkali and then with water, dried over Na2SO4, and evaporated under reduced pressure to give 28.8 g of crude 4-fluorobenzyl bromide. the mixture was refluxed for 2.0 hours the formed precipitate was removed by filtration the residual CCl4 solution was washed with dilute alkali with water, dried over Na2SO4 evaporated under reduced pressure

反应条件: temp:110.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 250 g (2.27 mols) of 4-fluorotoluene are added to 1.25 g (7.61 mmols) of α, α'-azoisobutyronitrile and heated to a temperature of 110° C. In the course of 4 hours, 725 g (4.54 mols) of bromine are added dropwise while raising the temperature of the reaction mixture to 145° C. 1.25 g (9.17 mmols) of zinc chloride are added to the mixture substantially consisting of 4-fluorobenzalbromide, and subsequently 40 g of water are added within 6 hours. After cooling to a temperature of 80° C. and addition of 1,160 g (930 ml) of 1,2-dichloroethane, the mixture is cooled to 150° C. Subsequently, 500 g of aluminum chloride are added portionwise to the mixture without exceeding a temperature of 20° C. Then, the mixture is heated to 40° C., and during 6 hours 382 g (2.39 mols) of bromine are added dropwise; afterwards, stirring of the mixture is continued for 16 hours at a temperature of 40° C. The reaction mixture is slowly poured onto a mixture of 2,400 g of ice and 105 g of concentrated hydrochloric acid, and thoroughly stirred for 5 minutes. The organic phase of the mixture is separated and washed twice with water and 10% aqueous sodium carbonate solution, respectively, and once with water. After evaporation of the 1,2-dichloroethane the product is fractionated. There are obtained 210 g (45%, relative to 4-fluorotoluene) of 3-bromo-4-fluorobenzaldehyde with a boiling range of 92° to 98° C. (at a pressure of 17 mbar) and a purity degree of more than 99%. while raising the temperature of the reaction mixture to 145° C are added within 6 hours the mixture is cooled to 150° C a temperature of 20° C Then, the mixture is heated to 40° C. thoroughly stirred for 5 minutes The organic phase of the mixture is separated washed twice with water and 10% aqueous sodium carbonate solution After evaporation of the 1,2-dichloroethane the product

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: By following the manipulative procedures described in Example 1(a) and (b), 24.0 g of 1-benzyl-4-piperidinol and 24.0 g of p-fluorotoluene produces an oil of 4-(p-tolyloxy)piperidine.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: By following the manipulative procedures described in Example 1(a) and (b), 24.0 g of 1-benzyl-4-piperidinol and 24.0 g of p-fluorotoluene produces an oil of 4-(p-tolyloxy)piperidine.