2-(tert-butylamino)acetonitrile;hydrochloride

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Under ice cooling and agitation, 818 mg of tert-butylaminoacetonitrile hydrochloride and 1.2 g of 7-hydroxyindole-2-carboxylic acid n-butyl ester are added to a solution of 2.7 g of aluminum chloride in 20 ml of nitrobenzene. Then gaseous hydrogen chloride is introduced into the mixture at 0° to 3° C. for 7 hours, the reaction mixture is stirred for 16 hours at 0°-3° C., and then poured into ice water. The mixture is agitated for 10 minutes and then the precipitate is vacuum-filtered. The precipitate is recrystallized from isopropanol, thus obtaining 765 mg of 4-tert-butylaminoacetyl-7-hydroxyindole-2-carboxylic acid n-butyl ester hydrochloride, decomposition point 203°-208° C. The mixture is agitated for 10 minutes the precipitate is vacuum-filtered The precipitate is recrystallized from isopropanol