2-羟甲基-4-甲氧基苯酚

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Other cyclic phosphites prepared as described above were 2-[4-methyl-2,6-bis(1,1-dimethylethyl)phenoxy]-6-methyl-4H-1,3,2-benzodioxaphosphorin, melting point 117°-123° C., molecular weight 486, by the reaction of 4-methyl-6-hydroxymethylphenol with 2,6-di-t-butyl-4-methylphenylphosphorodichloridite; 2-[2,4,6-tris(1,1-dimethylethyl)phenoxy]-6,8-bis(1,1-dimethylethyl)-4H-1,3,2-benzophosphorin, melting point 166°-255° C., molecular weight 526, by the reaction of 2,4,6-di-t-butyl-6-hydroxymethylphenol with 2,4,6-tri-t-butyl-phenylphosphorodichloridite; and 2-[2,4,6-tris(1,1-dimethylethyl)phenoxy]-8-(1,1-dimethylethyl)-4H-1,3,2-benzodioxaphosphorin, melting point 120°-127° C., molecular weight 470, by the reaction of 2-t-butyl-6-hydroxymethylphenol and 2,4,6-tri-t-butyl-phenylphosophorodichloridite. The structures were confirmed by Nuclear Magnetic Resonance and Infra-Red Analysis.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Other cyclic phosphites prepared as described above were 2-[4-methyl-2,6-bis(1,1-dimethylethyl)phenoxy]-6-methyl-4H-1,3,2-benzodioxaphosphorin, melting point 117°-123° C., molecular weight 486, by the reaction of 4-methyl-6-hydroxymethylphenol with 2,6-di-t-butyl-4-methylphenylphosphorodichloridite; 2-[2,4,6-tris(1,1-dimethylethyl)phenoxy]-6,8-bis(1,1-dimethylethyl)-4H-1,3,2-benzophosphorin, melting point 166°-255° C., molecular weight 526, by the reaction of 2,4,6-di-t-butyl-6-hydroxymethylphenol with 2,4,6-tri-t-butyl-phenylphosphorodichloridite; and 2-[2,4,6-tris(1,1-dimethylethyl)phenoxy]-8-(1,1-dimethylethyl)-4H-1,3,2-benzodioxaphosphorin, melting point 120°-127° C., molecular weight 470, by the reaction of 2-t-butyl-6-hydroxymethylphenol and 2,4,6-tri-t-butyl-phenylphosophorodichloridite. The structures were confirmed by Nuclear Magnetic Resonance and Infra-Red Analysis.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Other cyclic phosphites prepared as described above were 2-[4-methyl-2,6-bis(1,1-dimethylethyl)phenoxy]-6-methyl-4H-1,3,2-benzodioxaphosphorin, melting point 117°-123° C., molecular weight 486, by the reaction of 4-methyl-6-hydroxymethylphenol with 2,6-di-t-butyl-4-methylphenylphosphorodichloridite; 2-[2,4,6-tris(1,1-dimethylethyl)phenoxy]-6,8-bis(1,1-dimethylethyl)-4H-1,3,2-benzophosphorin, melting point 166°-255° C., molecular weight 526, by the reaction of 2,4,6-di-t-butyl-6-hydroxymethylphenol with 2,4,6-tri-t-butyl-phenylphosphorodichloridite; and 2-[2,4,6-tris(1,1-dimethylethyl)phenoxy]-8-(1,1-dimethylethyl)-4H-1,3,2-benzodioxaphosphorin, melting point 120°-127° C., molecular weight 470, by the reaction of 2-t-butyl-6-hydroxymethylphenol and 2,4,6-tri-t-butyl-phenylphosophorodichloridite. The structures were confirmed by Nuclear Magnetic Resonance and Infra-Red Analysis.

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 2-Hydroxymethyl-4-methylphenol (3.1 g, 22.4 mMol) was dissolved in CHCl3 (95 ml). The solution was treated with manganese dioxide (8.7 g, 100 mmol) and the reaction stirred at ambient temperature overnight under an argon atmosphere. The reaction was then filtered through Celite and the solvent evaporated. The residue was subjected to chromatography (eluant: ethyl ether/hexane) to give 2-hydroxy-5-methylbenzaldehyde as a pale green solid (0.63 g, 20.7%). The reaction was then filtered through Celite the solvent evaporated

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a suspension of LiAlH4 (2.5 g, 66 mmol) LiAlH4 in freshly distilled THF (8 ml) at 0° C. under argon, was added dropwise with stirring a solution of 5-methylsalicylic acid (5 g, 33 mmol) in freshly distilled THF (80 ml). Addition was complete in 0.75 hours and the reaction stirred at ambient temperature overnight. Careful addition of water (5 ml) was followed by the addition of ice (10 ml) and concentrated HCl (1 ml). The solvent was decanted and the residue treated with ethyl ether and ice water. The pH of the mixture was adjusted to pH 1 with concentrated HCl and the organic layer combined with the decanted solvent, washed with brine, dried (MgSO4) and evaporated. The residue was subjected to chromatography (eluant: ethyl ether/hexane) to give 2-hydroxymethyl-4-methylphenol as a white solid (3.1 g, 68%). was added dropwise Addition The solvent was decanted the residue treated with ethyl ether and ice water washed with brine dried (MgSO4) evaporated

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of 4.80 g of 4-fluoro-2-hydroxybenzoic acid in 100 ml of tetrahydrofuran is added dropwise at 0° C. to the suspension of 5.29 g of lithium aluminium hydride in 150 ml of tetrahydrofuran and stirred over 2 hours. The reaction mixture is admixed dropwise successively with 6 ml of water, 6 ml of 15% NaOH and 24 ml of water, and stirred over 1 hour. The mixture is filtered and the filtrate is concentrated by evaporation. The crude title compound is obtained as a red-orange oil from the residue. Rf=0.20 (1:1 EtOAc-heptane); Rt=2.47. stirred over 1 hour The mixture is filtered the filtrate is concentrated by evaporation

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of 4.80 g of 4-fluoro-2-hydroxybenzoic acid in 100 ml of tetrahydrofuran is added dropwise at 0° C. to the suspension of 5.29 g of lithium aluminium hydride in 150 ml of tetrahydrofuran and stirred over 2 hours. The reaction mixture is admixed dropwise successively with 6 ml of water, 6 ml of 15% NaOH and 24 ml of water, and stirred over 1 hour. The mixture is filtered and the filtrate is concentrated by evaporation. The crude title compound is obtained as a red-orange oil from the residue. Rf=0.20 (1:1 EtOAc-heptane); Rt=2.47. stirred over 1 hour The mixture is filtered the filtrate is concentrated by evaporation

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Other cyclic phosphites prepared as described above were 2-[4-methyl-2,6-bis(1,1-dimethylethyl)phenoxy]-6-methyl-4H-1,3,2-benzodioxaphosphorin, melting point 117°-123° C., molecular weight 486, by the reaction of 4-methyl-6-hydroxymethylphenol with 2,6-di-t-butyl-4-methylphenylphosphorodichloridite; 2-[2,4,6-tris(1,1-dimethylethyl)phenoxy]-6,8-bis(1,1-dimethylethyl)-4H-1,3,2-benzophosphorin, melting point 166°-255° C., molecular weight 526, by the reaction of 2,4,6-di-t-butyl-6-hydroxymethylphenol with 2,4,6-tri-t-butyl-phenylphosphorodichloridite; and 2-[2,4,6-tris(1,1-dimethylethyl)phenoxy]-8-(1,1-dimethylethyl)-4H-1,3,2-benzodioxaphosphorin, melting point 120°-127° C., molecular weight 470, by the reaction of 2-t-butyl-6-hydroxymethylphenol and 2,4,6-tri-t-butyl-phenylphosophorodichloridite. The structures were confirmed by Nuclear Magnetic Resonance and Infra-Red Analysis.