瑞加德松杂质37

反应条件: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of 3-bromo-6-hydrazinylimidazo[1,2-b]pyridazine (866 mg, 3.8 mmol) and methyl 2-formyl-3-oxopropanoate (500 mg, 3.8 mmol) in EtOH (20 mL) was heated at 70° C. overnight. The mixture was concentrated and treated with MeOH. The titled compound (410 mg) was collected by filtration. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 3.94 (s, 3H) 7.84 (s, 1H) 8.01 (d, J=9.60 Hz, 1H) 8.11 (d, J=9.60 Hz, 1H) 8.19 (s, 1H) 9.09 (s, 1H). The mixture was concentrated treated with MeOH The titled compound (410 mg) was collected by filtration

反应条件: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of 3-bromo-6-hydrazinylimidazo[1,2-b]pyridazine (866 mg, 3.8 mmol) and methyl 2-formyl-3-oxopropanoate (500 mg, 3.8 mmol) in EtOH (20 mL) was heated at 70° C. overnight. The mixture was concentrated and treated with MeOH. The titled compound (410 mg) was collected by filtration. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 3.94 (s, 3H) 7.84 (s, 1H) 8.01 (d, J=9.60 Hz, 1H) 8.11 (d, J=9.60 Hz, 1H) 8.19 (s, 1H) 9.09 (s, 1H). The mixture was concentrated treated with MeOH The titled compound (410 mg) was collected by filtration