1-METHOXY-3-(PIPERAZIN-1-YL)PROPAN-2-OL

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of 500 mg (1.67 mmol) of 8-chloro-7-fluoro-5-oxo-1,2-dihydro-5H-thiazolo(3,2-a)-quinoline-4-carboxylic acid and 1.45 grams (8.3 mmol) of N-(2-hydroxy-3-methoxy-1-propyl)-piperazine was suspended in 20 ml of pyridine and the mixture was heated to reflux for thirty six hours. When the reaction was completed, pyridine was evaporated therefrom under reduced pressure and ethanol was added to the residue. Insoluble matters were filtered, washed with ether, and recrystallized from acetonitrile to give the title compound as flaky crystals. Yield 397.8 mg (54.5 percent). Melting point 224° C. Elementary analysis calculated as C20H24FN3O5S: C 54.91, H 5.53, N 9.60; Found: C 54.94, H 5.55, N 9.60. the mixture was heated to reflux for thirty six hours pyridine was evaporated under reduced pressure and ethanol was added to the residue Insoluble matters were filtered washed with ether recrystallized from acetonitrile