METHOXY CARBONYL PHOSPHONIC ACID

反应条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 46 parts by weight of Na2 -salt of phosphonoformic acid methyl ester are dissolved in 90 parts by volume of water and 46 parts by weight of methyl hydrazine are added at 25° C. The mixture is stirred at 80° C. for 7 hours and allowed to cool. The residue is removed by suction filtration and the filtrate is evaporated in vacuo. The residue after evaporation is digested with ethyl alcohol and the such obtained crystals are again dissolved in a mixture of 70 parts by volume methanol and 200 parts by volume ethyl alcohol and thereafter precipitated. 90 parts by weight of Na2 -salt of phosphonoformic acid methyl hydrazide are obtained (yield 38%). are added at 25° C to cool The residue is removed by suction filtration the filtrate is evaporated in vacuo The residue after evaporation the such obtained crystals precipitated