多利甾醇

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 50 g of cholestadiene were dissolved in 800 ml of dry ethyl acetate to which 30 ml of acetic acid had previously been added and after addition of 1.5 g of platinum oxide the mixture was transferred to an autoclave of 2 1 volume. Hydrogenation was carried out at 50° C. and 10 atm hydrogen pressure and was complete after 24 h. After reaction was complete, the catalyst was filtered off, the solvent was concentrated in a rotary evaporator and the doristerol obtained was recrystallized from ethanol. Yield: 42.5 g (88.5%). The purity of the substance was confirmed with the aid of 1H-NMR and 13C-NMR spectroscopy. 17 g of 4-(propen-2-oxy)benzoyl chloride and 32 g of doristerol were dissolved in 200 ml of dry toluene and heated to reflux for 15 h. The solvent was then distilled off and the residue was recrystallized from ethanol; yield: 44.9 g (99%), m.p. 92° C. (n*105i). had previously been added was carried out at 50° C. After reaction the catalyst was filtered off the solvent was concentrated in a rotary evaporator

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 50 g of cholestadiene (98%, Aldrich GmbH, Steinheim) are dissolved in 800 ml of dry ethyl acetate to which 30 ml of acetic acid have been added, 1.5 g of platinum oxide are added, and the mixture is transferred into an autoclave with a capacity of 2 l. The hydrogenation is carried out at 50° C. and a hydrogen pressure of 10 atm and is generally complete after 24 hours. When the reaction is complete, the catalyst is filtered off, the solvent is removed on a rotary evaporator, and the doristerol obtained is recrystallized from ethanol. Yield: 42.5 g (88.5%). The purity of the substance is ensured with the aid of 1H-NMR and 13C-NMR spectroscopy. have been added is carried out at 50° C. the catalyst is filtered off the solvent is removed on a rotary evaporator