1H-吲哚-2-羰基 氯化物

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反应条件: temp:0.00; pressure:0.00; stir:

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反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a mixture of 1H-Indole-2-carboxylic acid (2.50 g, 15.5 mmol) and acetyl chloride (31 mL, 0.43 mol) in Et2O (31.5 mL) was added phosphorus pentachloride (3.55 g, 17.1 mmol) in portions, and the mixture was then heated under reflux for 1.5 hours. The cooled reaction mixture was concentrated under reduced pressure, and the crude product obtained thus was recrystallized from heptanes to give 1H-indole-2-carbonyl chloride (2.04 g, 73%) as yellow needles. the mixture was then heated under reflux for 1.5 hours The cooled reaction mixture was concentrated under reduced pressure the crude product obtained thus was recrystallized from heptanes

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反应条件: temp:0.00; pressure:0.00; stir: