2,6-二氯苄胺

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 2,6-Dichlorobenzylamine (0.020 mol) was reacted with carbon disulfide (0.020 mol) and iodomethane (0.019 mol) substantially as described in Example 1B above to obtain 1.5 g (32%) white crystals: mp 47°.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 2,6-Dichlorobenzylamine (0.020 mol) was reacted with carbon disulfide (0.020 mol) and iodomethane (0.019 mol) substantially as described in Example 1B above to obtain 1.5 g (32%) white crystals: mp 47°.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The title compound was prepared by essentially following the same procedures described for Intermediate XLIV, using (2,6-dichlorophenyl)methanamine and 2-bromoimidazo[2,1-b]thiazole-6-carboxylic acid as starting materials.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The title compound was prepared by essentially following the same procedures described for Intermediate I, using (2,6-dichlorophenyl)methanamine and ethyl 6-bromoimidazo[1,2-a]pyridine-2-carboxylate as starting materials.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 2,6-Dichlorobenzylamine (0.020 mol) was reacted with carbon disulfide (0.020 mol) and iodomethane (0.019 mol) substantially as described in Example 1B above to obtain 1.5 g (32%) white crystals: mp 47°.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 7-bromo-1-(2,6-dichlorobenzyl)-1,2,3,4-tetrahydropyrazino[2,3-b]pyrazine was prepared from 2-amino-3,5-dibromopyrazine as described in Example 1 by replacing 2-chloro-3,6-difluorobenzylamine in step 1 with 2,6-dichlorobenzylamine.

反应条件: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a mixture of 2,6-dichloro-3-nitropyridine (1.0 g, 5.18 mmol) and potassium carbonate (848 mg, 6.14 mmol) in 15 mL MeCN was added 2,6-dichlorobenzylamine (0.63 mL, 5.18 mmol) at 0° C. The reaction mixture was stirred for one hour at 0° C. and then for 10 hours at room temperature. The organic solvent was evaporated and the residue was purified by silica gel chromatography (EtOAc:Hex=1:10) giving 16 [511 mg]. for 10 hours at room temperature The organic solvent was evaporated the residue was purified by silica gel chromatography (EtOAc:Hex=1:10)

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 2,6-Dichlorobenzylamine (0.020 mol) was reacted with carbon disulfide (0.020 mol) and iodomethane (0.019 mol) substantially as described in Example 1B above to obtain 1.5 g (32%) white crystals: mp 47°.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The title compound was prepared by essentially following the same procedures described for Intermediate XLIV, using (2,6-dichlorophenyl)methanamine and 2-bromoimidazo[2,1-b]thiazole-6-carboxylic acid as starting materials.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The title compound was prepared by essentially following the same procedures described for Intermediate I, using (2,6-dichlorophenyl)methanamine and ethyl 6-bromoimidazo[1,2-a]pyridine-2-carboxylate as starting materials.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 2,6-Dichlorobenzylamine (0.020 mol) was reacted with carbon disulfide (0.020 mol) and iodomethane (0.019 mol) substantially as described in Example 1B above to obtain 1.5 g (32%) white crystals: mp 47°.