9-碘-9-硼杂二环[3.3.1]壬烷

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Following general procedure M and using 7-t-butyl-5-[isopropyl-(4-methoxy-phenyl)-amino]-3,3,6-trimethyl-2,3-dihydro-benzofuran (Compound 57, 0.032 g, 0.083 mmol) and 1M solution of 9-iodo-9-borabicyclo[3.3.1]nonane (B-iodo-9-BBN) in hexanes (0.2 mL, 0.2 mmol) in 0.6 mL of anhydrous dichloromethane and 1 mL of n-pentane, the title compound (0.04 g) was obtained as a brown oil that was used in the next step without further purification.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Following general procedure M and using 7-t-butyl-5-[isopropyl-(4-methoxy-phenyl)-amino]-3,3,6-trimethyl-2,3-dihydro-benzofuran (Compound 57, 0.032 g, 0.083 mmol) and 1M solution of 9-iodo-9-borabicyclo[3.3.1]nonane (B-iodo-9-BBN) in hexanes (0.2 mL, 0.2 mmol) in 0.6 mL of anhydrous dichloromethane and 1 mL of n-pentane, the title compound (0.04 g) was obtained as a brown oil that was used in the next step without further purification.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Following general procedure M and using 7-t-butyl-5-[ethyl-(4-methoxy-phenyl)-amino]-3,3,6-trimethyl-2,3-dihydro-benzofuran (Compound 56, 0.12 g, 0.3 mmol) and 1M solution of 9-iodo-9-borabicyclo[3.3.1]nonane (B-iodo-9-BBN) in hexanes (0.44 mL, 0.44 mmol) in 2 mL of anhydrous dichloromethane, the title compound was obtained as a brown oil that was used in the next step without further purification.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Following general procedure M and using 7-isopropyl-5-[isopropyl-(4-methoxy-phenyl)-amino]-3,3,6-trimethyl-2,3-dihydro-benzofuran (Compound 55, 0.077 g, 0.21 mmol) and 1M solution of 9-iodo-9-borabicyclo[3.3.1]nonane (B-iodo-9-BBN) in hexanes (0.25 mL, 0.25 mmol) in 2 mL of anhydrous dichloromethane, the title compound (0.06 g, 77%) was obtained as a brown oil that was used in the next step without further purification.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Following general procedure M and using 7-isopropyl-5-[isopropyl-(4-methoxy-phenyl)-amino]-3,3,6-trimethyl-2,3-dihydro-benzofuran (Compound 55, 0.077 g, 0.21 mmol) and 1M solution of 9-iodo-9-borabicyclo[3.3.1]nonane (B-iodo-9-BBN) in hexanes (0.25 mL, 0.25 mmol) in 2 mL of anhydrous dichloromethane, the title compound (0.06 g, 77%) was obtained as a brown oil that was used in the next step without further purification.