呋喃-3-碳酰肼

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: As in Example 39, 3-furoic acid hydrazide is reacted with 5-chloro-2-cyanophenyl isothiocyanate to produce 2-(3-furyl)-5-mercapto-[1,2,4]triazolo[1,5-c]quinazoline, mp>300°, which is converted to the 5-methylthio compound and thence to 9-chloro-2-(3-furyl)-5-imino-5,6-dihydro[1,2,4]triazolo[1,5-c]quinazoline, purified as the methanesulphonate salt, mp 290°-292°.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Ethyl 3-furancarboxylate (7.0 g) and hydrazine monohydrate (4.8 ml) in ethanol (10 ml) were heated at reflux while stirring for 6 hours. The solvent was evaporated under reduced pressure, and the thus-precipitated crystals were recrystallized from ethanol, thereby giving 3.2 g of the desire compound. at reflux The solvent was evaporated under reduced pressure the thus-precipitated crystals were recrystallized from ethanol

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: As in Example 39, 3-furoic acid hydrazide is reacted with 5-chloro-2-cyanophenyl isothiocyanate to produce 2-(3-furyl)-5-mercapto-[1,2,4]triazolo[1,5-c]quinazoline, mp>300°, which is converted to the 5-methylthio compound and thence to 9-chloro-2-(3-furyl)-5-imino-5,6-dihydro[1,2,4]triazolo[1,5-c]quinazoline, purified as the methanesulphonate salt, mp 290°-292°.