2-甲基氨基苯甲酰胺

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a stirred mixture of 7.97 g of 2-methylaminobenzamide and 200 ml of ether was added dropwise, a solution of 10 g of 3-methylbenzoyl isothiocyanate in ether over 10 minutes. After 48 hours the solid was collected, giving 15.5 g of N-[[[2-aminocarbonyl)phenyl]methylamino]thioxomethyl]-3-methylbenzamide. was added dropwise After 48 hours the solid was collected

反应条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: N-Methylisatic acid (10.0 g) is added gradually to water (140 ml) at room temperature and thereto is added dropwise aqueous ammonia (9.6 g). The mixture is warmed to 80° C. during 45 minutes, and ethanol is added thereto until the reaction mixture becomes colorless. Then, the reaction mixture is cooled to room temperature and the precipitated crystals are collected by filtration to give 2-carbamoyl-N-methylaniline (7.11 g) as colorless crystal. Then, the reaction mixture is cooled to room temperature the precipitated crystals are collected by filtration

反应条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: N-Methylisatic acid (10.0 g) is added gradually to water (140 ml) at room temperature and thereto is added dropwise aqueous ammonia (9.6 g). The mixture is warmed to 80° C. during 45 minutes, and ethanol is added thereto until the reaction mixture becomes colorless. Then, the reaction mixture is cooled to room temperature and the precipitated crystals are collected by filtration to give 2-carbamoyl-N-methylaniline (7.11 g) as colorless crystal. Then, the reaction mixture is cooled to room temperature the precipitated crystals are collected by filtration

反应条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 10.0 g of N-methylisatic acid are added gradually to 140 ml of water at a room temperature and 9.6 g of aqueous ammonia are added dropwise thereto. The mixture is warmed to a temperature of 80° C. during 45 minutes and ethanol is added thereto until the reaction mixture becomes colorless. Then, the reaction mixture is cooled to a room temperature and the precipitated crystals are collected by filtration to obtain 7.11 of 2-carbamoyl-N-methylaniline as colorless crystal. Then, the reaction mixture is cooled to a room temperature the precipitated crystals are collected by filtration

反应条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 10.0 g of N-methylisatic acid are added gradually to 140 ml of water at a room temperature and 9.6 g of aqueous ammonia are added dropwise thereto. The mixture is warmed to a temperature of 80° C. during 45 minutes and ethanol is added thereto until the reaction mixture becomes colorless. Then, the reaction mixture is cooled to a room temperature and the precipitated crystals are collected by filtration to obtain 7.11 of 2-carbamoyl-N-methylaniline as colorless crystal. Then, the reaction mixture is cooled to a room temperature the precipitated crystals are collected by filtration

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: N-Methylisatic acid (10.0 g) is added gradually to water (140 ml) at room temperature and thereto is added dropwise aqueous ammonia (9.6 g). The mixture is warmed to 80° C. during 45 minutes, and ethanol is added thereto until the reaction mixture becomes colorless. Then, the reaction mixture is cooled to room temperature and the precipitated crystals are collected by filtration to give 2-carbamoyl-N-methylaniline (7.11 g) as colorless crystal. Then, the reaction mixture is cooled to room temperature the precipitated crystals are collected by filtration

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The title product was prepared from 2-(methylamino)benzamide and 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate, preparative HPLC (method C) (57%, light yellow oil). HPLC-MS m/z=454.2 (M+Na), Rt: 3.66 min.

反应条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 10.0 g of N-methylisatic acid are added gradually to 140 ml of water at a room temperature and 9.6 g of aqueous ammonia are added dropwise thereto. The mixture is warmed to a temperature of 80° C. during 45 minutes and ethanol is added thereto until the reaction mixture becomes colorless. Then, the reaction mixture is cooled to a room temperature and the precipitated crystals are collected by filtration to obtain 7.11 g of 2-carbamoyl-N-methylaniline as colorless crystal. Then, the reaction mixture is cooled to a room temperature the precipitated crystals are collected by filtration