1-溴-4,4,4-三氟丁烷-2-酮

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Prepared in analogy to example 49 (a) from 1-piperazinecarbothioamide and 1-bromo-4,4,4-trifluoro-butan-2-one. The crude material was purified by chromatography (SiO2, methanol/dichloromethane) to yield the title compound as a brown oil (yield 24%). MS (m/e): 252.3 (M+H+, 100%). The crude material was purified by chromatography (SiO2, methanol/dichloromethane)

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The title compound was prepared using the same experimental procedure as in examples 18f and 18g from 2-{1-[(benzyloxy)methyl]cyclobutyl}ethanethioamide and 1-bromo-4,4,4-trifluoro-2-butanone. 1H NMR (300 MHz, CDCl3) δ 7.25 (s, 1H), 3.35 (s, 2H), 2.82 (br s, 2H), 2.02-1.91 (m, 6H).