N-(2,5-二氟苯基)甲酰胺

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of 9.9 g of 2B, 25 ml of dimethylformamide, 11 g of 1A and 2 g of triethylamine (catalyst) was heated in a steam bath for 24 hours. The resulting mixture was diluted with ether and water, and phase-separated. The ether phase was washed with water, and dried (MgSO4), and the solvent was evaporated. The residue was triturated with ether. The residual off-white solid was 2, m.p.: 118°-120° C. was heated in a steam bath for 24 hours phase-separated The ether phase was washed with water dried (MgSO4) the solvent was evaporated The residue was triturated with ether

反应条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of 25.8 g of 2A, 18.5 g of formic acid and 100 ml of benzene was refluxed (80° C.) for 2 hours. The mixture was allowed to stand overnight. The solid that formed was separated and taken up in ether. Hexane was added. The solid that formed was separated and washed with cold hexane to give N-(2,5-difluorophenyl)formamide (2B), m.p.: 112°-114° C. The solid that formed was separated Hexane was added The solid that formed was separated washed with cold hexane