4 - 叠氮丁-1 -胺

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of fenbufen (214 mg, 0.8 mmol), HBTU (302 mg, 0.8 mmol), DIEA (1 mL, 0.8 mmol) and DMF (15 mL) was stirred. 4-azido-1-butanamine was added. TLC (acetone/n-hexane= 3/7) indicated the consumption of starting material (Rf=0.39) and the formation of the product (Rf=0.78). After stirring for 1 hr, the mixture was concentrated under high vacuum at 60° C. The residue was purified by flash chromatography using acetone: n-hexane=3:7 as eluents to provide a snow-white solid in 77% yield (269 mg). the consumption of starting material (Rf=0.39) the mixture was concentrated under high vacuum at 60° C The residue was purified by flash chromatography n-hexane=3:7 as eluents to provide a snow-white solid in 77% yield (269 mg)

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of fenbufen (214 mg, 0.8 mmol), HBTU (302 mg, 0.8 mmol), DIEA (1 mL, 0.8 mmol) and DMF (15 mL) was stirred. 4-azido-1-butanamine was added. TLC (acetone/n-hexane= 3/7) indicated the consumption of starting material (Rf=0.39) and the formation of the product (Rf=0.78). After stirring for 1 hr, the mixture was concentrated under high vacuum at 60° C. The residue was purified by flash chromatography using acetone: n-hexane=3:7 as eluents to provide a snow-white solid in 77% yield (269 mg). the consumption of starting material (Rf=0.39) the mixture was concentrated under high vacuum at 60° C The residue was purified by flash chromatography n-hexane=3:7 as eluents to provide a snow-white solid in 77% yield (269 mg)

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of fenbufen (214 mg, 0.8 mmol), HBTU (302 mg, 0.8 mmol), DIEA (1 mL, 0.8 mmol) and DMF (15 mL) was stirred. 4-azido-1-butanamine was added. TLC (acetone/n-hexane= 3/7) indicated the consumption of starting material (Rf=0.39) and the formation of the product (Rf=0.78). After stirring for 1 hr, the mixture was concentrated under high vacuum at 60° C. The residue was purified by flash chromatography using acetone: n-hexane=3:7 as eluents to provide a snow-white solid in 77% yield (269 mg). the consumption of starting material (Rf=0.39) the mixture was concentrated under high vacuum at 60° C The residue was purified by flash chromatography n-hexane=3:7 as eluents to provide a snow-white solid in 77% yield (269 mg)