阿伐那非杂质81

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Added to 40 ml of toluene were 600 mg (3.92 mmol) of 3-hydroxy-4-methoxybenzylamine and 810 mg (3.90 mmol) of 2,6-diisopropylphenyl isocyanate, and the mixture was stirred under reflux for 8 hours. under reflux for 8 hours

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a suspension of (3Z)-3-(1-hydroxyethylidene)-4-phenylpiperidine-2,6-dione (0.12 g, 0.52 mmol) and 5-(aminomethyl)-2-methoxyphenol (98 mg, 0.52 mmol) in absolute ethanol (5 mL) is added sodium acetate (0.75 mmol). The mixture is heated at reflux overnight and then allowed to cool to room temperature. The solvent is evaporated under reduced pressure and the residue is triturated with diethyl ether. The solid is collected, washed with diethyl ether, water, and methanol, and dried under vacuum to give (3Z)-3-{1-[(3-hydroxy-4-methoxybenzyl)amino]ethylidene}-4-phenylpiperidine-2,6-dione as a white powder (0.17 g, 88%). The mixture is heated at reflux overnight The solvent is evaporated under reduced pressure the residue is triturated with diethyl ether The solid is collected washed with diethyl ether, water, and methanol dried under vacuum

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Added to 40 ml of toluene were 600 mg (3.92 mmol) of 3-hydroxy-4-methoxybenzylamine and 810 mg (3.90 mmol) of 2,6-diisopropylphenyl isocyanate, and the mixture was stirred under reflux for 8 hours. under reflux for 8 hours

反应条件: temp:0.00; pressure:0.00; stir: