双(4-氯苄基)偶氮二甲酸酯

反应条件: temp:45.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a solution of 1-(2-aminopyrimidin-4-yl)-2-(tert-butyldimethylsilyloxy)ethanol (19) (640 mg), 2-Chloro-4-fluorophenol (696 mg) and triphenylphosphine (1246 mg) in dichloromethane (10 mL) was added a solution of (E)-bis(4-chlorobenzyl) diazene-1,2-dicarboxylate in dichloromethane (20 mL) dropwise. The mixture was stirred at 45° C. overnight before being filtered and the filtrate was applied to a silica column and eluted with 10 to 100% ether in heptane. The product containing fractions were concentrated to afford the title compound (835 mg) as a white solid. before being filtered eluted with 10 to 100% ether in heptane The product containing fractions were concentrated