乙基 2-氯-4,4-二氟-3-氧代丁酸乙酯

反应条件: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 8.84 g 4-Methoxythiobenzamide were dissolved in 100 ml ethanol and warmed to 50° C. Then 10.59 g 2-chloro-4,4-difluoro-3-oxo-butyric acid ethyl ester were added and the reaction mixture stirred under reflux for three hours. The cooled reaction mixture was evaporated in vacuo and the residue purified by chromatograph on silica gel with the eluent ethyl acetate/petroleum benzene=1:4 to obtain 7.04 g 4-difluoromethyl-2-(4-methoxy-phenyl)-thiazole-5-carboxylic acid ethyl ester as pale yellow solid. under reflux for three hours The cooled reaction mixture was evaporated in vacuo the residue purified by chromatograph on silica gel with the eluent ethyl acetate/petroleum benzene=1:4

反应条件: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 8.84 g 4-Methoxythiobenzamide were dissolved in 100 ml ethanol and warmed to 50° C. Then 10.59 g 2-chloro-4,4-difluoro-3-oxo-butyric acid ethyl ester were added and the reaction mixture stirred under reflux for three hours. The cooled reaction mixture was evaporated in vacuo and the residue purified by chromatograph on silica gel with the eluent ethyl acetate/petroleum benzene=1:4 to obtain 7.04 g 4-difluoromethyl-2-(4-methoxy-phenyl)-thiazole-5-carboxylic acid ethyl ester as pale yellow solid. under reflux for three hours The cooled reaction mixture was evaporated in vacuo the residue purified by chromatograph on silica gel with the eluent ethyl acetate/petroleum benzene=1:4

反应条件: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 8.84 g 4-Methoxythiobenzamide were dissolved in 100 ml ethanol and warmed to 50° C. Then 10.59 g 2-chloro-4,4-difluoro-3-oxo-butyric acid ethyl ester were added and the reaction mixture stirred under reflux for three hours. The cooled reaction mixture was evaporated in vacuo and the residue purified by chromatograph on silica gel with the eluent ethyl acetate/petroleum benzene=1:4 to obtain 7.04 g 4-difluoromethyl-2-(4-methoxy-phenyl)-thiazole-5-carboxylic acid ethyl ester as pale yellow solid. under reflux for three hours The cooled reaction mixture was evaporated in vacuo the residue purified by chromatograph on silica gel with the eluent ethyl acetate/petroleum benzene=1:4