(8AS)-1,5,6,7,8,8A-六氢噁唑并[3,4-A]吡嗪-3-酮

反应条件: temp:135.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of (S)-tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one (1.42 g, 10.000 mmol), 1,6-dichlorophthalazine (1.47 g, 7.39 mmol) and N,N-DIPEA (5.00 mL, 30.0 mmol) in 12 mL DMF was heated at 135° C. The crude material was purified by flash chromatography eluting with 2 M NH3 in MeOH/CH2Cl2 (0:1→3:97) to give 1.85 g of a brown oil. MS m/z: 305.1, 307.1 [M+1]. The crude material was purified by flash chromatography eluting with 2 M NH3 in MeOH/CH2Cl2 (0:1→3:97)

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The title compound 16 is synthesized from intermediate D (0.100 g, 0.220 mmol) and (S)-hexahydro-oxazolo[3,4-a]pyrazin-3-one (48.0 mg, 0.269 mmol) according to the procedure described for the synthesis of compound 11.