N-甲基-2-氧代丙烷-1-磺酰胺

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The title compound 80 is prepared according to the procedure reported in Example 27 with aldehyde 79 (104.4 mg, 0.40 mmol), N-methyl-2-oxo-propane-1-sulfonamide [prepared as described by Builla et al in Tetrahedron 1998, 3589](60.4 mg, 0.40 mmol) and benzylamine (42.8 mg, 0.40 mmol) as reactants. Purification by column chromatography on SiO2 (gradient of EtOAc in Petroleum Ether) afford the title compound 80 as a yellow solid. (Yield 77.1 mg, 40%). The title compound 80 is prepared Purification by column chromatography on SiO2 (gradient of EtOAc in Petroleum Ether)