(R)-2-BOC-氨甲基吡咯烷

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Prepared analogously to Example 1g from N-[1-(1-tert-butoxycarbonyl-5-chloro-1H-benzimidazol-2-yl)-3-hydroxycarbonylpropyl]-3-methyl-4-(pyrrolidin 1-ylcarbonyl)benzamide, TBTU, diisopropylethylamine, (R)-2-tert-butoxycarbonylaminomethylpyrrolidine in acetonitrile, and subsequent reaction with trifluoroacetic acid analogously to Example 17. Yield: 51%; Rf value: 0.59 (silica gel; ethyl acetate/ethanol=7:3); C34H43ClN6O5 (651.20); mass spectrum: (M+H)+=651/653 (chlorine isotope).